My Patient Information Sail For The Influenza Vaccine For Informed Consent.
My Patient Info Sheet for the Flu Vaccine for Informed Consent
For the Pro side delight see the https://www.cdc.gov/flu/
It is of import to review both sets of information to brand an informed decision.
1. Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al ... (n.d.). Retrieved from https://residenciadeclinica.files.wordpress.com/2010/08/influenza-vaccines-cochrane-review-20101.pdf
Collaboration report included xl clinical trial studies of to a greater extent than than 70,000 people a perfectly matched year, it showed upward to 80% create goodness but since that oftentimes doesn’t happen, it listed 50% effectiveness to equally depression equally 30% effectiveness with the flu vaccine. So merely equally many people theoretically benefited equally didn’t on an average year. It showed small-scale days lost from run in addition to NO evidence was flora to decrease hospitalization or complication rates. Another analysis lay it this way. When the vaccine matched the flu strain, 4 percentage who weren’t vaccinated got the flu. One percentage of vaccinated people got it. That’s a divergence of 3 percent. When the vaccine didn’t tally the strain, 2 percentage of unvaccinated people got the flu, in addition to 1 percentage didn’t, for a divergence of 1 percent.
2. Kelley NS, Manske JM, Ballering KS, Leighton TR, Moore KA. The Compelling Need for Game-Changing Influenza Vaccines, An analysis of the flu vaccine enterprise in addition to recommendations for the future. Center for Infectious Disease Research & Policy, Oct 2012.
It removed to a greater extent than of the “flawed” studies in addition to flora that inwards a perfectly matched year, it was 59% effective inwards having the vaccine inwards the ages of 18-64. It showed no create goodness inwards the elderly (over 65) or nether xviii has been seen inwards other studies. Their newspaper suggests that the flu vaccine is non ideal but due to lack of fiscal incentive, to a greater extent than beneficial vaccines are non probable to hold out found.
3. Cowling, Fang, Kwok-Hung. Increased Non-Influenza Respiratory Virus Infections Associated with receipt of the Inactivated Influenza Vaccine. Clinical Infectious Diseases, Vol. 54, Issue 12, June 2012 pages 1778-1783, also inwards Clin Infect Dis 2012 June 15; 54(12): 1778-83
TIV (trivalent inactivated flu vaccine) recipients had higher jeopardy of confirmed non-influenza respiratory virus infection (RR, 3.46;95% Cl, 1.19-10.1) The bulk of the non-influenzas respiratory virus detection were rhinoviruses in addition to coxsackie/echoviruses, in addition to the increased jeopardy alongside TIV recipients was also statistically important for these viruses.
4. Minn, Michael, McCullers, J., Klugman, K. Live Attenuated Influenza Vaccine Enhance Colonization of Steptococcus Pneumonia in addition to Staphylococcus Aureus inwards Mice, mBio 5(1) doi:10.1128/mBio.01040-13
The strong in addition to oftentimes lethal effects of an antecedent flu virus infection on secondary bacterial illness convey been reported. Viral replication induced epithelial in addition to mucosal degradation, in addition to the ensuing innate immune answer yield diminished capacity to avert secondary bacterial infections. Recent clinical in addition to experimental information propose that flu virus infection may exert its influence firstly inwards the URT past times enhancing susceptibility to bacterial colonization.
5. Goldman GS Comparison of VAERS fetal-loss reports during 3 consecutive flu seasons: Was at that spot a synergistic fetal toxicity associated with the two- vaccine 2009-2019 season? Hum. Exp Toxicol. 2013 May;32(5): 464-75
There were 77.8 fetal loss reports per 1 meg important women vaccinated during the 2009/2010 2 dose flu flavor vs 6.8 fetal loss reports during the previous 1-dose flu season. An 11.4-fold increase. The 2 multidose vials incorporate 25 mcg of mercury per dose those years.
6. Jefferson T, Rivetti A, et al. Vaccines for preventing flu inwards salubrious children. Cochrane Database Syst. Rev 2012 Aug 15; Issue 8: CD 004879
75 worldwide studies, Inc 17 randomized trials, inwards children older than 2, the inactivated flu vaccine is close 36% effective. Under 2 it was equal to placebo, no evidence to demonstrate reduced mortality, infirmary admissions, serious complications or community transmission of influenza.
7. Jefferson T, Smith S, et al. Assessment of the efficacy in addition to effectiveness of flu vaccines inwards salubrious children: systematic review. Lancet 2005 February 26; 365 (9461) : 773-80
No evidence of reduced mortality, admissions, complications, or decreased community transmission of influenza.
8. Joshi, AY, Iyer VN, et al. Effectiveness of trivalent inactivated flu vaccine inwards influenza-related hospitalization inwards children: a case-control study. Allergy Ashthma Proc 2012 Mar-Apr;33(2): e23-7
Study of kids vi months to xviii years from 1999-2007. Children who were vaccinated against flu were 3 times to a greater extent than probable to hold out hospitalized for flu related complications than children who did non have an flu vaccine (OR=3.67). Asthmatic children who received the flu vaccine were also to a greater extent than probable to hold out hospitalized than those who did non have it. The severity of asthma did non touching on the outcome.
9. Seasonal Influenza in addition to Vaccine Herd Effect
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083064
Study 1968-2001-Observational study showed no decreased mortality charge per unit of measurement with increasing vaccination from 15% to 65%
10.Thomas RE, Jefferson T, Lasserson TJ Influenza vaccination for wellness tending workers who tending for people aged threescore or older living inwards long-term tending institutions. Cochrane Database Syst Rev 2013 ; Issue 7: CD 005187
No evidence to back upward that vaccinating healthcare workers inwards long-term tending facilities showed effect on laboratory proven flu or complications (pneumonia, hospitalization, or decease due to pneumonia) inwards those residence over historic flow 60.
11. Doshi, P. (2013). Influenza: Marketing vaccine past times marketing disease. Bmj, 346(May16 1). doi:10.1136/bmj.f3037
Too much to listing to explicate but worth the read.
12. Doshi, P. (2005). Are USA flu decease figures to a greater extent than PR than science? Bmj, 331(7529), 1412. doi:10.1136/bmj.331.7529.1412
(Basically, discusses this information on this page)
13. Carrat, F., Lavenu, A. et al, Repeated flu vaccination of salubrious children in addition to adults borrow now, pay later? Epidemiol. Infect. (2006) 134, 63-70
Shows that repeated flu vaccination at a younger historic flow substantially increases the jeopardy of flu inwards older age
14.Phone conversation with (protected cite now), MD, MPH, CAPT, USPHS Medical Officer Epidemiology in addition to Prevention Branch Influenza Division, NCIRD Centers for Disease Control in addition to Prevention
Agreed with all information hither in addition to says this is the best nosotros tin do. Due to lack of evidence, they create non officially endorse flu vaccine mandates. Also she admits that nosotros volition never convey adept studies due to changing viral strains in addition to vaccines that may non match.
15. Skowronski DM, De Serres G, et al. Association betwixt 2008-2009 seasonal flu vaccine in addition to pandemic H1N1 illness during Spring-Summer 2009:four observational studies from Canada PLoS Med 2010 Apr 6; 7(4) e1000258
Recipients of the flu vaccine had significantly increment flu compared to those who didn’t. Recipients had increased demand for requiring medical attending due to the H1N1 virus.
16. Link: Carl Grays article on Time Management http://www.bmj.com/cgi/content/full/316/7137/S2-7137 seemed to larn ... (1998). Bmj, 316(7149). doi:10.1136/bmj.316.7149.3a
“In adjusted models, nosotros observed 6.3 (95% CI 1.9–21.5) times to a greater extent than aerosol shedding alongside cases with vaccination inwards the electrical flow in addition to previous flavor compared with having no vaccination inwards those 2 seasons.”
“those who were vaccinated 3 years inwards a row genuinely had an increased jeopardy of contracting flu compared with unvaccinated participants....”
Prior twelvemonth vaccination cutting the electrical flow twelvemonth efficacy of the flu vaccine.
Children who larn the flu vaccine convey 3 times the charge per unit of measurement of hospitalization for flu.
20.Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion in addition to Enhance Influenza Virus Respiratory Disease, Sci Transl Med 28 August 2013: Vol. 5, Issue 200, p. 200ra114 Sci. Transl. Med.
"A novel study inwards the U.S. has shown that pigs vaccinated against ane strain of flu were worse off if afterward infected past times a related strain of the virus."
21.Effectiveness of trivalent inactivated flu vaccine inwards influenza-related hospitalization inwards children: a case-control study. Joshi AY1, Iyer VN, Hartz MF, Patel AM, Li JT
TIV (The inactivated flu vaccine) did non render whatever protection against hospitalization inwards pediatric subjects, peculiarly children with asthma. On the contrary, nosotros flora a threefold increased jeopardy of hospitalization inwards subjects who did larn the TIV vaccine.
22.Influenza vaccines seem to hold out modifying flu into a unsafe dengue similar disease.
23.Death rates due to actual positive flu tests average nether 1000 per twelvemonth inwards over 300,000,000 patients according to the CDC National Vital Statistics Report. The number that you lot take heed inwards the media of 30K to 50K deaths are due to flu AND pneumonia (all displace pneumonia including from HIV, COPD, elderly, cancer etc). The number is inflated to increment flu vaccination. Pediatric flu deaths are reportable in addition to attain from 60-120 annually. Adult flu deaths are non reportable but obtained via decease certificates in addition to thus that gives liberty for "estimation" to larn from a 1000 to the 10's of thousands with no existent proof. It is foreign that if at that spot are 30-50K deaths from flu in addition to pneumonia that 80% would hold out from flu when it alone happens a few months out of the year.
24. Adverse reactions- flawed due to reporter bias. Our grooming is to state that whatever important flu similar illness is probable coincidence or would convey been worse without the vaccine. We are non trained to recognize serum sickness in addition to nosotros are also also busy to report.
Miller’s Review of Critical Vaccine Studies used equally a resource
25.Nanri, A., Nakamoto, K., Sakamoto, N., Imai, T., Akter, S., Nonaka, D., & Mizoue, T. (2017). Association of serum 25-hydroxyvitamin D with flu inwards case-control study nested inwards a cohort of Japanese employees. Clinical Nutrition, 36(5), 1288-1293. doi:10.1016/j.clnu.2016.08.016
Lower flu jeopardy associated with vitamin D sufficiency alongside unvaccinated participants warrants farther investigation.
Link:
26. Roos R. Study: Prior-year vaccination cutting flu vaccine effects inwards 2014-15. CIDRP News. In: Center for Infectious Disease Research in addition to Policy website. Available at http://www.cidrap.umn.edu/news-perspective/2016/04/study-prior-year-vaccination-cut-flu-vaccine-effects-2014-15. Accessed 08Nov16.
27. Smith DJ, Forrest S, Ackley DH, Perelson AS. Variable efficacy of repeated annual flu vaccination. Proc Natl Acad Sci U due south H5N1 1999; 96:14001–6. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24180/pdf/pq014001.pdf.
28. Skowronski, D. M., & Serres, G. D. (2018). Role of Egg-adaptation Mutations inwards Low Influenza A(H3N2) Vaccine Effectiveness During the 2012–2013 Season. Clinical Infectious Diseases. doi:10.1093/cid/ciy350
Using a illustration command study pattern in addition to information from Canada's Sentinel Practitioner Surveillance Network (SPSN) for the 2014-2015 flu season, Dr. Skowronski’s grouping reported that study participants who received the 2014–2015 vaccine without vaccination the twelvemonth earlier had important protection against flu A(H3N2) but those who had received the identical 2013-2014 vaccine the previous twelvemonth had no increased protection in addition to those who were vaccinated 3 years inwards a row genuinely had an increased jeopardy of contracting flu compared with unvaccinated participants.
29. Systemic autoimmunity appears to hold out the inevitable number of over-stimulating the host’s immune arrangement past times repeated immunization.
30. The Autoimmune/Inflammatory Syndrome induced past times adjuvants (ASIA)
31.Subgroup analysis demonstrates that immunosuppressive therapies in addition to the nonadjuvanted Pb to less immunogenicity inwards humoral answer inwards flu-vaccinated SLE patients.
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